The global health sector has experienced a dynamic year. Innovation saw significant progress with the administration of the first-ever customized CRISPR therapy to treat a baby’s genetic disease. Promising trials demonstrated new immunotherapies curing cancers, and the search for cancer vaccines also advanced. Novo Nordisk, led by CEO , launched the first GLP-1 pill onto the market. Furthermore, after the Trump Administration reduced funding for international aid and medical research, leaders worldwide stepped in to help fill these financial voids. This year, —the individuals most influential in the world of health right now—are more crucial than ever.

The selection of these 100 individuals involved months of consultation with global sources and experts by our team of health correspondents and editors, spearheaded by Emma Barker Bonomo and Mandy Oaklander. This rigorous process revealed a diverse community comprising scientists, doctors, advocates, educators, policymakers, and others—each leading in their respective fields—who are collectively transforming global health.